A deep learning approach with subregion partition in MRI image analysis for metastatic brain tumor.

ABSTRACT:

Purpose

To propose a deep learning network with subregion partition for predicting metastatic origins and EGFR/HER2 status in patients with brain metastasis.

Methods

We retrospectively enrolled 140 patients with clinico-pathologically confirmed brain metastasis originated from primary NSCLC (n = 60), breast cancer (BC, n = 60) and other tumor types (n = 20). All patients underwent contrast-enhanced brain MRI scans. The brain metastasis was subdivided into phenotypically consistent subregions using patient-level and population-level clustering. A residual network with a global average pooling layer (RN-GAP) was proposed to calculate deep learning-based features. Features from each subregion were selected with least absolute shrinkage and selection operato

SUBMITTER: Shi J 

PROVIDER: S-EPMC9382021 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature