Gut microbiota may be involved in Alzheimer's disease pathology by dysregulating pyrimidine metabolism in APP/PS1 mice.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is the most common form of dementia worldwide. The biological mechanisms underlying the pathogenesis of AD aren't completely clear. Studies have shown that the gut microbiota could be associated with AD pathogenesis; however, the pathways involved still need to be investigated.

Aims

To explore the possible pathways of the involvement of gut microbiota in AD pathogenesis through metabolites and to identify new AD biomarkers.

Methods

Seven-month-old APP/PS1 mice were used as AD models. The Morris water maze test was used to examine learning and memory ability. 16S rRNA gene sequencing and widely targeted metabolomics were used to identify the gut microbiota composition and fecal metabolic profile, respectively, followed by a combine

SUBMITTER: Feng M 

PROVIDER: S-EPMC9382084 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature