Mechanisms of damage prevention, signalling and repair impact disease tolerance.

ABSTRACT: The insect gut is frequently exposed to pathogenic threats and must not only clear these potential infections, but also tolerate relatively high microbe loads. In contrast to the mechanisms that eliminate pathogens, we currently know less about the mechanisms of disease tolerance. We investigated how well-described mechanisms that prevent, signal, control or repair damage during infection contribute to the phenotype of disease tolerance. We established enteric infections with the bacterial pathogen Pseudomonas entomophila in transgenic lines of Drosophila melanogaster fruit flies affecting dcy (a major component of the peritrophic matrix), upd3 (a cytokine-like molecule), irc (a negative regulator of reactive oxygen species) and egfr¹ (e

SUBMITTER: Prakash A 

PROVIDER: S-EPMC9382215 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature