Stable Chelation of the Uranyl Ion by Acyclic Hexadentate Ligands: Potential Applications for ²³⁰U Targeted α-Therapy.

ABSTRACT: Uranium-230 is an α-emitting radionuclide with favorable properties for use in targeted α-therapy (TAT), a type of nuclear medicine that harnesses α particles to eradicate cancer cells. To successfully implement this radionuclide for TAT, a bifunctional chelator that can stably bind uranium in vivo is required. To address this need, we investigated the acyclic ligands H₂dedpa, H₂CHXdedpa, H₂hox, and H₂CHXhox as uranium chelators. The stability constants of these ligands with UO₂²⁺ were measured via spectrophotometric titrations, revealing log β_ML values that are greater than 18 and 26 for the "pa" and "hox" chelators, respectively, signifying that the resulting complexes are exceedingly stable. In addition, the UO

SUBMITTER: Woods JJ 

PROVIDER: S-EPMC9382226 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature