Heterogeneous interactions and polymer entropy decide organization and dynamics of chromatin domains.

ABSTRACT: Chromatin is known to be organized into multiple domains of varying sizes and compaction. While these domains are often imagined as static structures, they are highly dynamic and show cell-to-cell variability. Since processes such as gene regulation and DNA replication occur in the context of these domains, it is important to understand their organization, fluctuation, and dynamics. To simulate chromatin domains, one requires knowledge of interaction strengths among chromatin segments. Here, we derive interaction-strength parameters from experimentally known contact maps and use them to predict chromatin organization and dynamics. Taking two domains on the human chromosome as examples, we investigate its three-dimensional organization, size/shape fluctuations, and dynamics of different seg

SUBMITTER: Kumari K 

PROVIDER: S-EPMC9382282 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature