Tryptophan metabolism is a physiological integrator regulating circadian rhythms.

ABSTRACT:

Objective

The circadian clock aligns physiology with the 24-hour rotation of Earth. Light and food are the main environmental cues (zeitgebers) regulating circadian rhythms in mammals. Yet, little is known about the interaction between specific dietary components and light in coordinating circadian homeostasis. Herein, we focused on the role of essential amino acids.

Methods

Mice were fed diets depleted of specific essential amino acids and their behavioral rhythms were monitored and tryptophan was selected for downstream analyses. The role of tryptophan metabolism in modulating circadian homeostasis was studied using isotope tracing as well as transcriptomic- and metabolomic- analyses.

Results

Dietary tryptophan depletion alters behavioral rhythms in mice. Furthermor

SUBMITTER: Petrus P 

PROVIDER: S-EPMC9382333 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature