Identifying novel mechanisms of abdominal aortic aneurysm via unbiased proteomics and systems biology.

ABSTRACT:

Background

Abdominal aortic aneurysm (AAA), characterized by a continued expansion of the aorta, leads to rupture if not surgically repaired. Mice aid the study of disease progression and its underlying mechanisms since sequential studies of aneurysm development are not feasible in humans. The present study used unbiased proteomics and systems biology to understand the molecular relationship between the mouse models of AAA and the human disease.

Methods and results

Aortic tissues of developing and established aneurysms produced by either angiotensin II (AngII) infusion in Apoe ^-/- and Ldlr ^-/- mice or intraluminal elastase incubation in wildtype C57BL/6J mice were examined. Aortas were dissected free and separated into eight anatomical seg

SUBMITTER: Morgan S 

PROVIDER: S-EPMC9382335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature