Design and validation of a FHIR-based EHR-driven phenotyping toolbox.

ABSTRACT:

Objectives

To develop and validate a standards-based phenotyping tool to author electronic health record (EHR)-based phenotype definitions and demonstrate execution of the definitions against heterogeneous clinical research data platforms.

Materials and methods

We developed an open-source, standards-compliant phenotyping tool known as the PhEMA Workbench that enables a phenotype representation using the Fast Healthcare Interoperability Resources (FHIR) and Clinical Quality Language (CQL) standards. We then demonstrated how this tool can be used to conduct EHR-based phenotyping, including phenotype authoring, execution, and validation. We validated the performance of the tool by executing a thrombotic event phenotype definition at 3 sites, Mayo Clinic (MC), Northwestern Medic

SUBMITTER: Brandt PS 

PROVIDER: S-EPMC9382394 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature