MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.

ABSTRACT: Granulosa cells of growing ovarian follicles elaborate filopodia-like structures termed transzonal projections (TZPs) that supply the enclosed oocyte with factors essential for its development. Little is known, however, of the mechanisms underlying the generation of TZPs. We show in mouse and human that filopodia, defined by an actin backbone, emerge from granulosa cells in early stage primary follicles and that actin-rich TZPs become detectable as soon as a space corresponding to the zona pellucida appears. mRNA encoding Myosin10 (MYO10), a motor protein that accumulates at the base and tips of filopodia and has been implicated in their initiation and elongation, is present in granulosa cells and oocytes of growing follicles. MYO10 protein accumulates in foci located mainly between the oo

SUBMITTER: Granados-Aparici S 

PROVIDER: S-EPMC9382396 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature