Association of Anticancer Immune Checkpoint Inhibitors With Patient-Reported Outcomes Assessed in Randomized Clinical Trials: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The association of immune checkpoint inhibitors (ICIs) with patient quality of life has been poorly explored.

Objective

To evaluate patient-reported outcomes (PROs) assessed in randomized clinical trials (RCTs) of immunotherapy-based treatments.

Data sources

This systematic review and random-effects meta-analysis used RCTs identified in PubMed, MEDLINE, Embase, and Scopus from database inception to June 1, 2021.

Study selection

A total of 2259 RCTs were identified that assessed ICIs as monotherapy or in combination with chemotherapy or combined with another ICI and/or targeted therapy vs control groups not containing immunotherapy in patients with advanced solid tumors. Studies were reviewed independently by 2 authors.

Data extraction and synthesi

SUBMITTER: Pala L 

PROVIDER: S-EPMC9382448 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature