Rapid and selective generation of H₂S within mitochondria protects against cardiac ischemia-reperfusion injury.

ABSTRACT: Mitochondria-targeted H₂S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H₂S that decreases oxidative damage. However, the rate of H₂S release by current donors is too slow to be effective upon administration following reperfusion. To overcome this limitation here we develop a mitochondria-targeted agent, MitoPerSulf that very rapidly releases H₂S within mitochondria. MitoPerSulf is quickly taken up by mitochondria, where it reacts with endogenous thiols to generate a persulfide intermediate that releases H₂S. MitoPerSulf is acutely protective against cardiac IR injury in mice, due to the acute generation of H₂S that inhibits respiration at cytochrome c oxidase thereby preventing mi

SUBMITTER: Miljkovic JL 

PROVIDER: S-EPMC9382561 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature