Nasal carriage of CTX-M-55-producing Escherichia coli ST8369 in a healthy cohort in the city of Yangzhou, China.

ABSTRACT: This study aimed to investigate the prevalence and diversity of extended-spectrum β-lactamases (ESBL)-producing Escherichia coli isolates from healthy individuals in a community and to elucidate their dissemination mechanism. Cefotaxime-resistant E. coli were isolated from 95 samples of healthy persons from one community in Yangzhou, China, and were tested for minimal inhibitory concentrations of 14 antimicrobial agents. The isolates were subjected to whole genome sequencing by Illumina Hiseq or PacBio single-molecule real-time sequencing. A total of 30 cefotaxime-resistant E. coli isolates were obtained, carrying bla _CTX-M (n=29) or bla _DHA (n=1), of which the bla _CTX-M-55 (n=19) was the most predominant genotype.

SUBMITTER: Wang ZY 

PROVIDER: S-EPMC9382594 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature