High-Throughput Biofilm Assay to Investigate Bacterial Interactions with Surface Topographies.

ABSTRACT: The specific topography of biomaterials plays an important role in their biological interactions with cells and thus the safety of medical implants. Antifouling materials can be engineered with topographic features to repel microbes. Meanwhile, undesired topographies of implants can cause complications such as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). While the cause of BIA-ALCL is not well understood, it is speculated that textured surfaces are prone to bacterial biofilm formation as a contributing factor. To guide the design of safer biomaterials and implants, quantitative screening approaches are needed to assess bacterial adhesion to different topographic surface features. Here we report the development of a high-throughput microplate biofilm assay for such s

SUBMITTER: Lee SW 

PROVIDER: S-EPMC9382637 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature