Second trimester short cervix is associated with decreased abundance of cervicovaginal lipid metabolites.

ABSTRACT:

Background

A short cervix is a risk factor for preterm birth. The molecular drivers of a short cervix remain elusive. Metabolites may function as mediators of pathologic processes.

Objective

We sought to determine if a distinct cervicovaginal metabolomic profile is associated with a short cervix (<25 mm) to unveil the potential mechanisms by which premature cervical remodeling leads to a short cervix.

Study design

This was a secondary analysis of a completed prospective pregnancy cohort. Cervicovaginal fluid was obtained between 20 and 24 weeks' gestation. The participants selected for metabolomic profiling were frequency-matched by birth outcome and cervicovaginal microbiota profile. This analysis included 222 participants with cervical length measured. A short cervi

SUBMITTER: Gerson KD 

PROVIDER: S-EPMC9382664 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature