Ultrasound-assisted laser thrombolysis with endovascular laser and high-intensity focused ultrasound.

ABSTRACT:

Purpose

The combination of laser and ultrasound can significantly improve the efficiency of thrombolysis through an enhanced cavitation effect. We developed a fiber optics-based laser-ultrasound thrombolysis device and tested the feasibility and efficiency of this technology for restoring blood flow in an in vitro blood clot model.

Methods

An in vitro blood flow-clot model was setup, and then an endovascular laser thrombolysis system was combined with high-intensity focused ultrasound to remove the clot. The laser and ultrasound pulses were synchronized and delivered to the blood clot concurrently. The laser pulses of 532 nm were delivered to the blood clot endovascularly through an optical fiber, whereas the ultrasound pulses of 0.5 MHz were applied noninvasively to the sam

SUBMITTER: Jo J 

PROVIDER: S-EPMC9382677 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature