Expression profile and prognostic value of CXCR family members in head and neck squamous cell carcinoma.

ABSTRACT:

Background

CXC chemokine receptor gene family consists of seven well-established members which are broadly involved in biological functions of various cancers. Currently, limited studies have shed light on the expression profile of CXCR family members (CXCRs), as well as their prognostic value, in head and neck squamous cells carcinoma (HNSCC).

Methods

The data for this study were retrieved from the Cancer Genome Atlas database and other publicly available databases, including gene expression, methylation profiles, clinical information, immunological features, and prognoses. The expression pattern and prognostic values of CXCRs were identified, and the potential mechanism underlying CXCRs function in HNSCC was investigated by gene set enrichment analysis (GSEA).

Results</

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9382762 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature