Optimization of the production process for the anticancer lead compound illudin M: downstream processing.

ABSTRACT:

Background

Secondary metabolites have played a key role as starting points for drug development programs due to their often unique features compared with synthetically derived molecules. However, limitations related to the discovery and supply of these molecules by biotechnological means led to the retraction of big pharmaceutical companies from this field. The reasons included problems associated with strain culturing, screening, re-discovery, purification and characterization of novel molecules from natural sources. Nevertheless, recent reports have described technical developments that tackle such issues. While many of these reports focus on the identification and characterization of such molecules to enable subsequent chemical synthesis, a biotechnological supply strategy is ra

SUBMITTER: Chaverra-Munoz L 

PROVIDER: S-EPMC9382783 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature