Discovery and validation of tissue-specific DNA methylation as noninvasive diagnostic markers for colorectal cancer.

ABSTRACT:

Background

Noninvasive diagnostic markers that are capable of distinguishing patients with colorectal cancer (CRC) from healthy individuals or patients with other cancer types are lacking. We report the discovery and validation of a panel of methylation-based markers that specifically detect CRC.

Methods

This was a large-scale discovery study based on publicly available datasets coupled with a validation study where multiple types of specimens from six cohorts with CRC, other cancer types, and healthy individuals were used to identify and validate the tissue-specific methylation patterns of CRC and assess their diagnostic performance.

Results

In the discovery and validation cohort (N = 9307), ten hypermethylated CpG sites located in three genes, C20orf194, LIFR, and Z

SUBMITTER: Li D 

PROVIDER: S-EPMC9382793 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature