Expression of TRAF6 in peripheral blood B cells of patients with myasthenia gravis.

ABSTRACT:

Background

Tumor necrosis factor receptor-associated factor 6 (TRAF6) can regulate the activation of inflammatory signaling pathways by acting as an E3 ubiquitin ligase, which enhances B cell activation. This study aimed to evaluate the expression of TRAF6 in the peripheral blood B cells of myasthenia gravis (MG) patients and analyze the relationships between TRAF6 expression and clinical characteristics.

Method

In our study, the expression level of TRAF6 in peripheral blood B cells of 89 patients was measured by flow cytometry compared with that of healthy subjects. The effects of disease severity, MG classification and immunotherapy on TRAF6 expression level were also analyzed.

Results

In our study, TRAF6 expression was elevated in CD19⁺ B cells and CD19<

SUBMITTER: Li T 

PROVIDER: S-EPMC9382794 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature