Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial.

ABSTRACT:

Background

The antiviral efficacy of remdesivir in COVID-19 hospitalized patients remains controversial.

Objectives

To estimate the effect of remdesivir in blocking viral replication.

Methods

We analysed nasopharyngeal normalized viral loads from 665 hospitalized patients included in the DisCoVeRy trial (NCT04315948; EudraCT 2020-000936-23), randomized to either standard of care (SoC) or SoC + remdesivir. We used a mathematical model to reconstruct viral kinetic profiles and estimate the antiviral efficacy of remdesivir in blocking viral replication. Additional analyses were conducted stratified on time of treatment initiation (≤7 or >7 days since symptom onset) or viral load at randomization (< or ≥3.5 log10 copies/104 cells).

Results

In our model, remdesivir

SUBMITTER: Lingas G 

PROVIDER: S-EPMC9383489 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature