Enhanced development of functional human NK cells in NOD-scid-IL2rg^null mice expressing human IL15.

ABSTRACT: Human innate immunity plays a critical role in tumor surveillance and in immunoregulation within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that have opposing roles in the tumor microenvironment, including NK cell subsets that mediate tumor cell cytotoxicity and subsets with regulatory function that contribute to the tumor immune suppressive environment. The balance between effector and regulatory NK cell subsets has been studied extensively in murine models of cancer, but there is a paucity of models to study human NK cell function in tumorigenesis. Humanized mice are a powerful alternative to syngeneic mouse tumor models for the study of human immuno-oncology and have proven effective tools to test immunotherapies targeting T cells. However, human NK

SUBMITTER: Aryee KE 

PROVIDER: S-EPMC9383543 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature