Reliably Assessing Duration of Protection for COVID-19 Vaccines.

ABSTRACT: Decision-making about vaccination and boosting schedules for COVID-19 hinges on reliable methods for evaluating the longevity of vaccine protection. We show that modeling of protection as a piecewise linear function of time since vaccination for the log hazard ratio of the vaccine effect provides more reliable estimates of vaccine effectiveness at the end of an observation period and also more reliably detects plateaus in protective effectiveness as compared with the traditional method of estimating a constant vaccine effect over each time period. This approach will be useful for analyzing data pertaining to COVID-19 vaccines and other vaccines where rapid and reliable understanding of vaccine effectiveness over time is desired.

SUBMITTER: Lin DY 

PROVIDER: S-EPMC9383791 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature