Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates.

ABSTRACT: The introduction of fluorine atoms into organic molecules is an attractive but challenging topic. In this work, an interesting palladium-catalyzed difluoroalkylative carbonylation of aryl olefins has been developed. A wide range of aryl olefins were transformed into the corresponding difluoropentanedioate compounds with good functional-group tolerance and excellent regioselectivity. Inexpensive ethyl bromodifluoroacetate acts both as a difluoroalkyl precursor and a nucleophile here. Additionally, a scale-up reaction was also performed successfully, and further transformations of the obtained product were shown as well.

SUBMITTER: Bao ZP 

PROVIDER: S-EPMC9384137 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature