MERS-CoV infection elicits long-lasting specific antibody, T and B cell immune responses in recovered individuals.

ABSTRACT:

Background

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic zoonotic betacoronaviruses and a global public health concern. Better undersetting of the immune responses to MERS-CoV is needed to characterize the correlates of protection and durability of the immunity and to aid in developing preventative and therapeutic interventions. While MERS-CoV-specific circulating antibodies could persist for several years post-recovery, their waning raises concerns about their durability and role in protection. Nonetheless, memory B and T cells could provide long-lasting protective immunity despite the serum antibodies levels.

Methods

Serological and flow cytometric analysis of MERS-CoV-specific immune responses were performed on samples collected from a

SUBMITTER: Alhabbab RY 

PROVIDER: S-EPMC9384236 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature