Isavuconazole plasma concentrations in critically ill patients during extracorporeal membrane oxygenation.

ABSTRACT:

Background

Isavuconazole is an antifungal drug used for treatment of invasive fungal infections. Critically ill COVID-19 and influenza patients require extracorporeal membrane oxygenation (ECMO) in cases with severe acute respiratory distress syndrome and have risk factors for invasive pulmonary aspergillosis. Little is known about isavuconazole plasma concentrations during ECMO.

Objectives

To determine isavuconazole plasma concentrations in seven patients treated with intravenous isavuconazole under ECMO and the influence of the ECMO circuit immediately after the first isavuconazole dose.

Methods

Critically ill patients treated with isavuconazole (standard doses) and ECMO were included in this study. Sixty-four blood samples used for measurement of isavuconazole conc

SUBMITTER: Kriegl L 

PROVIDER: S-EPMC9384295 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature