Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers.

ABSTRACT: The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous booster vaccination after Ad26.COV2.S priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

SUBMITTER: Sablerolles RSG 

PROVIDER: S-EPMC9384313 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature