Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity.

ABSTRACT: The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude, claiming millions of lives and pushing healthcare systems in many countries to the brink. Among several factors that contribute to an increased risk of COVID-19 and progression to exacerbated manifestations, host genetic landscape is increasingly being recognized as a critical determinant of susceptibility/resistance to infection and a prognosticator of clinical outcomes in infected individuals. Recently, several case-control association studies investigated the influence of human gene variants on COVID-19 susceptibility and severity to identify the culpable mutations. However, a comprehensive synthesis of the recent advances in COVID-19 host genetics research was lacking, and the inconsistent findings of th

SUBMITTER: Gupta K 

PROVIDER: S-EPMC9384365 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature