Interpatient variability in the pharmacokinetics of remdesivir and its main metabolite GS-441524 in treated COVID-19 subjects.

ABSTRACT:

Background

Remdesivir is the first antiviral drug against SARS-CoV-2 approved for use in COVID-19 patients.

Objectives

To study the pharmacokinetic inter-individual variability of remdesivir and its main metabolite GS-441524 in a real-world setting of COVID-19 inpatients and to identify possible associations with different demographic/biochemical variables.

Methods

Inpatients affected by SARS-CoV-2 infections, undergoing standard-dose remdesivir treatment, were prospectively enrolled. Blood samples were collected on day 4, immediately after (C0) and at 1 h (C1) and 24 h (C24) after infusion. Remdesivir and GS-441524 concentrations were measured using a validated UHPLC-MS/MS method and the AUC0-24 was calculated. At baseline, COVID-19 severity (ICU or no ICU), sex, age

SUBMITTER: Tempestilli M 

PROVIDER: S-EPMC9384469 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature