Dataset Information

Development of an effective immune response in adults with Down Syndrome after SARS-CoV-2 vaccination.

ABSTRACT:

Background

Immune dysregulation in individuals with Down syndrome (DS) leads to an increased risk for hospitalization and death due to COVID-19 and may impair the generation of protective immunity after vaccine administration.

Methods

The cellular and humoral responses of 55 DS patients who received a complete SARS-CoV-2 vaccination regime at one to three (V1) and six (V2) months were characterized.

Results

SARS-CoV-2-reactive CD4 + and CD8+ T lymphocytes with a predominant Th1 phenotype were observed at V1 and increased at V2. Likewise, an increase of SARS-CoV-2-specific circulating Tfh (cTfh) cells and CD8+ CXCR5+ PD-1hi lymphocytes were already observed at V1 after vaccine administration. Specific IgG antibodies against SARS-CoV-2 S protein were detected in 96% and 98% of subjects at V1 and V2, respectively, though IgG titers decreased significantly between both timepoints.

Conclusions

Our findings show that DS individuals develop an effective immune response to usual regimes of SARS-CoV-2 vaccination.

SUBMITTER: Esparcia-Pinedo L

PROVIDER: S-EPMC9384526 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Development of an Effective Immune Response in Adults With Down Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination.

Esparcia-Pinedo Laura L Yarci-Carrión Ayla A Mateo-Jiménez Gloria G Ropero Noelia N Gómez-Cabañas Laura L Lancho-Sánchez Ángel Á Almendro-Vázquez Patricia P Martín-Gayo Enrique E Paz-Artal Estela E Sanchez-Madrid Francisco F Moldenhauer Fernando F Gutiérrez-Cobos Ainhoa A Real de Asúa Diego D Alfranca Arantzazu A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20230201 3

<h4>Background</h4>Immune dysregulation in individuals with Down syndrome (DS) leads to an increased risk for hospitalization and death due to coronavirus disease 2019 (COVID-19) and may impair the generation of protective immunity after vaccine administration.<h4>Methods</h4>The cellular and humoral responses of 55 individuals with DS who received a complete SARS-CoV-2 vaccination regime at 1 to 3 (visit [V 1]) and 6 (V2) months were characterized.<h4>Results</h4>SARS-CoV-2-reactive CD4+ and CD ...[more]

PMID: 35869848

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