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Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status.


ABSTRACT: The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting.

SUBMITTER: Fonseca PLC 

PROVIDER: S-EPMC9384558 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status.

Fonseca Paula L C PLC   Moreira Filipe R R FRR   de Souza Rafael M RM   Guimarães Natália R NR   Carvalho Nara O NO   Adelino Talita E R TER   Alves Hugo J HJ   Alvim Luige B LB   Candido Darlan S DS   Coelho Helena P HP   Costa Alana V B AVB   Costa Walyson C WC   de Carvalho Alex F AF   de Faria Bruna W F BWF   de Lima Aline B AB   de Oliveira Eneida S ES   de Souza Carolina S A CSA   de Souza Fernanda G FG   Dias Rillery C RC   Geddes Victor E V VEV   Godinho Igor P IP   Gonçalves Alessandro L AL   Lourenço Karine L KL   Magalhães Rubens D M RDM   Malta Frederico S V FSV   Medeiros Eva L A ELA   Mendes Fernanda S FS   Mendes Pedro H B de P PHBP   Mendonça Cristiane P T B CPTB   Menezes Andre L AL   Menezes Diego D   Menezes Mariane T MT   Miguita Lucyene L   Moreira Rennan G RG   Peixoto Renata B RB   Queiroz Daniel C DC   Ribeiro Adriana A AA   Ribeiro Ana Paula de B APB   Saliba Juliana W JW   Sato Hugo I HI   Silva Joice do P JDP   Silva Natiely P NP   Faria Nuno R NR   Teixeira Santuza M R SMR   da Fonseca Flávio G FG   Fernandes Ana Paula S M APSM   Zauli Danielle A G DAG   Januario José Nélio JN   de Oliveira Jaqueline S JS   Iani Felipe C de M FCM   de Aguiar Renato S RS   de Souza Renan P RP  

Virus evolution 20220727 2


The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain R  ...[more]

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