Omicron-associated changes in SARS-CoV-2 symptoms in the United Kingdom.

ABSTRACT:

Background

The SARS-CoV-2 Delta variant has been replaced by the highly transmissible Omicron BA.1 variant, and subsequently by Omicron BA.2. It is important to understand how these changes in dominant variants affect reported symptoms, while also accounting for symptoms arising from other co-circulating respiratory viruses.

Methods

In a nationally representative UK community study, the COVID-19 Infection Survey, we investigated symptoms in PCR-positive infection episodes vs. PCR-negative study visits over calendar time, by age and vaccination status, comparing periods when the Delta, Omicron BA.1 and BA.2 variants were dominant.

Results

Between October-2020 and April-2022, 120,995 SARS-CoV-2 PCR-positive episodes occurred in 115,886 participants, with 70,683 (58%) re

SUBMITTER: Vihta KD 

PROVIDER: S-EPMC9384604 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature