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Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.

ABSTRACT: In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/M titers showed positive correlation with neutralizing antibody titers (rs = 0.80 [95% confidence interval, .72-.86]; P < .001) and S peptide-stimulated interferon-γ concentrations (rs = 0.31 [.13-.47]; P < .001).

SUBMITTER: Vivaldi G 

PROVIDER: S-EPMC9384605 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.

Vivaldi Giulia G   Jolliffe David A DA   Faustini Sian S   Shields Adrian M AM   Holt Hayley H   Perdek Natalia N   Talaei Mohammad M   Tydeman Florence F   Chambers Emma S ES   Cai Weigang W   Li Wenhao W   Gibbons Joseph M JM   Pade Corinna C   McKnight Áine Á   Shaheen Seif O SO   Richter Alex G AG   Martineau Adrian R AR  

The Journal of infectious diseases 20221101 11

In this population-based cohort of 7538 adults, combined immunoglobulin (Ig) G, IgA, and IgM (IgG/A/M) anti-spike titers measured after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-spike IgG/A/  ...[more]

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