Hyperimmune Globulin for Severely Immunocompromised Patients Hospitalized With Coronavirus Disease 2019: A Randomized, Controlled Trial.
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ABSTRACT: Background
The aim of this randomized, controlled trial is to determine whether antisevere acute respiratory syndrome coronavirus 2 hyperimmune globulin (COVIG) protects against severe coronavirus disease 2019 (COVID-19) in severely immunocompromised, hospitalized, COVID-19 patients.Methods
Patients were randomly assigned to receive COVIG or intravenous immunoglobulin (IVIG) without SARS-CoV-2 antibodies.Results
Severe COVID-19 was observed in 2 of 10 (20%) patients treated with COVIG compared to 7 of 8 (88%) in the IVIG control group (P = .015, Fisher's exact test).Conclusions
Antisevere acute respiratory syndrome coronavirus 2 hyperimmune globulin may be a valuable treatment in severely immunocompromised, hospitalized, COVID-19 patients and should be considered when no monoclonal antibody therapies are available.
SUBMITTER: Huygens S
PROVIDER: S-EPMC9384649 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Hyperimmune Globulin for Severely Immunocompromised Patients Hospitalized With Coronavirus Disease 2019: A Randomized, Controlled Trial.
Huygens Sammy S Hofsink Quincy Q Nijhof Inger S IS Goorhuis Abraham A Kater Arnon P AP Te Boekhorst Peter A W PAW Swaneveld Francis F Novotný Věra M J VMJ Bogers Susanne S Welkers Matthijs R A MRA Papageorgiou Grigorios G Rijnders Bart J BJ Heijmans Jarom J
The Journal of infectious diseases 20230101 2
<h4>Background</h4>The aim of this randomized, controlled trial is to determine whether antisevere acute respiratory syndrome coronavirus 2 hyperimmune globulin (COVIG) protects against severe coronavirus disease 2019 (COVID-19) in severely immunocompromised, hospitalized, COVID-19 patients.<h4>Methods</h4>Patients were randomly assigned to receive COVIG or intravenous immunoglobulin (IVIG) without SARS-CoV-2 antibodies.<h4>Results</h4>Severe COVID-19 was observed in 2 of 10 (20%) patients treat ...[more]
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