Low molecular weight heparin is associated with better outcomes than unfractionated heparin for thromboprophylaxis in hospitalized COVID-19 patients: a meta-analysis.

ABSTRACT:

Aims

This study aimed to compare the outcomes of the administration of LMWH and UFH in hospitalized COVID-19 patients.

Methods and results

We systematically searched several databases and included observational studies or clinical trials that compared the outcomes of the administration of LMWH and UFH in hospitalized COVID-19 patients. A total of nine studies comprising 9637 patients were included. Metanalysis showed that LMWH administration was associated with a lower in-hospital mortality and 28/30-day mortality compared with UFH administration {[relative risk (RR) 0.44; 95% confidence interval (95% CI) 0.32-0.61; I2: 87.9%] and (RR 0.45; 95% CI 0.24-0.86; I2: 78.4%), respectively}. Patient with LMWH had shorter duration of hospital and ICU length of stay compared with UFH

SUBMITTER: Alsagaff MY 

PROVIDER: S-EPMC9384651 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature