Activity of ertapenem/zidebactam (WCK 6777) against problem Enterobacterales.

ABSTRACT:

Background

Secondary healthcare will remain pressured for some years, both because SARS-CoV-2 will circulate as a nosocomial pathogen, and owing to backlogs of patients awaiting delayed elective procedures. These stresses will drive the use of Outpatient Parenteral Antibiotic Therapy (OPAT), which will need to cover increasingly resistant Gram-negative opportunists. We evaluated the activity of ertapenem/zidebactam, proposed for 2 + 2 g q24h administration.

Materials and methods

MICs were determined, by BSAC agar dilution, for 1632 Enterobacterales submitted to the UK national reference laboratory for investigation of antimicrobial resistance.

Results

Over 90% of Escherichia coli with AmpC, ESBLs, KPC, metallo- or OXA-48 carbapenemases were inhibited by ertapenem/zide

SUBMITTER: Mushtaq S 

PROVIDER: S-EPMC9384802 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature