Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.

ABSTRACT: The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both in vivo experiments and in silico simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 μm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transp

SUBMITTER: Xue Y 

PROVIDER: S-EPMC9385041 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature