Niclosamide-loaded nanoparticles disrupt Candida biofilms and protect mice from mucosal candidiasis.

ABSTRACT: Candida albicans biofilms are a complex multilayer community of cells that are resistant to almost all classes of antifungal drugs. The bottommost layers of biofilms experience nutrient limitation where C. albicans cells are required to respire. We previously reported that a protein Ndu1 is essential for Candida mitochondrial respiration; loss of NDU1 causes inability of C. albicans to grow on alternative carbon sources and triggers early biofilm detachment. Here, we screened a repurposed library of FDA-approved small molecule inhibitors to identify those that prevent NDU1-associated functions. We identified an antihelminthic drug, Niclosamide (NCL), which not only prevented growth on acetate, C. albicans hyphenation and early biofilm growth, but also completely disengaged fully grown biof

SUBMITTER: Sutar Y 

PROVIDER: S-EPMC9385045 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature