Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations.

ABSTRACT:

Background

Multiple sclerosis is characterised by inflammation, oligodendrocyte loss and axonal demyelination and shows an additional impact on astrocytes, and their polarization. Although a certain degree of spontaneous myelin repair can be observed, disease progression, and aging impair regeneration efforts highlighting the need to better understand glial cell dynamics to establish specific regenerative treatments.

Methods

Applying a chronic demyelination model, we here analysed demyelination and remyelination related effects on astrocytes and stem cell niches and studied the consequences of medrysone application on myelin repair, and astrocyte polarization.

Findings

Medrysone induced recovery of mature oligodendrocytes, myelin expression and node formation. In addi

SUBMITTER: Silva Oliveira Junior M 

PROVIDER: S-EPMC9385547 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature