Prognostic value of IGFBP2 in various cancers: a systematic review and meta-analysis.

ABSTRACT:

Background

The prognostic significance of insulin-like growth factor binding protein 2 (IGFBP2) expression has been explored in plenty of studies in human cancers. Because of the controversial results, the meta-analysis was carried out to evaluate the relevance of IGFBP2 expression with the prognosis in various tumors.

Methods

The data searched from four databases (Pubmed, Embase, Cochrane library, and Web of science) was used to calculate pooled hazard ratios (HRs) in this meta-analysis. Subgroup analyses were stratified by ethnicity, cancer type, publication year, Newcastle-Ottawa Scale score, treatments, and populations.

Results

Twenty-one studies containing 5560 patients finally met inclusion criteria. IGFBP2 expression was associated with lower overall survival (

SUBMITTER: Zhang B 

PROVIDER: S-EPMC9385590 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature