Clinicopathological characteristics, survival outcomes, and genetic alterations of younger patients with gastric cancer: Results from the China National Cancer Center and cBioPortal datasets.

ABSTRACT:

Background

The survival outcomes of younger patients with gastric cancer (GC) have remained controversial. This study explores the clinicopathological characteristics, survival outcomes, and genetic alterations of younger and older patients with GC.

Methods

Patients with GC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1998-2018. Survival analysis was conducted using Kaplan-Meier estimates and Cox proportional hazards models. Sequencing datasets were enrolled from The Cancer Genome Atlas (TCGA) and Memorial Sloan-Kettering Cancer Center (MSKCC) databases.

Results

A total of 1146 younger (<40 years of age) and 16,988 older (≥40 years of age) cases were included in the study. Younger patients had more poorly differentiate

SUBMITTER: Niu P 

PROVIDER: S-EPMC9385592 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature