Protective effect of rosiglitazone on microscopic and oxidative stress parameters of ram sperm after freeze-thawing.

ABSTRACT: The purpose of this study was to investigate the effects of rosiglitazone on ram semen after cryopreservation on the quality of thawed sperm. Sperm motility, membrane functionality, viability, total abnormality, acrosome membrane integrity, mitochondrial activity, reactive oxygen species production, ATP content and apoptotic features were assessed after thawing. Rosiglitazone at concentration of 60 µM resulted in the highest (P < 0.05) total motility, progressive motility and straight-line velocity. The percentages of average path velocity and curvilinear velocity were greater in the 60 µM group. Different concentrations of rosiglitazone did not have significant effects on amplitude of the lateral head displacement, linearity and straightness. The highest amounts of membrane functionality

SUBMITTER: Mehdipour M 

PROVIDER: S-EPMC9385643 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature