Wearable adjunct ozone and antibiotic therapy system for treatment of Gram-negative dermal bacterial infection.

ABSTRACT: The problematic combination of a rising prevalence of skin and soft tissue infections and the growing rate of life-threatening antibiotic resistant infections presents an urgent, unmet need for the healthcare industry. These evolutionary resistances originate from mutations in the bacterial cell walls which prevent effective diffusion of antibiotics. Gram-negative bacteria are of special consideration due to the natural resistance to many common antibiotics due to the unique bilayer structure of the cell wall. The system developed here provides one solution to this problem through a wearable therapy that delivers and utilizes gaseous ozone as an adjunct therapy with topical antibiotics through a novel dressing with drug-eluting nanofibers (NFs). This technology drastically increases the se

SUBMITTER: Roth A 

PROVIDER: S-EPMC9385669 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature