Sex influences clinical phenotype in frontotemporal dementia.

ABSTRACT:

Introduction

Frontotemporal dementia (FTD) encompasses a wide spectrum of genetic, clinical, and histological findings. Sex is emerging as a potential biological variable influencing FTD heterogeneity; however, only a few studies explored this issue with nonconclusive results.

Objective

To estimate the role of sex in a single-center large cohort of FTD patients.

Methods

Five hundred thirty-one FTD patients were consecutively enrolled. Demographic, clinical, and neuropsychological features, survival rate, and serum neurofilament light (NfL) concentration were determined and compared between sex.

Results

The behavioral variant of FTD was more common in men, whereas primary progressive aphasia was overrepresented in women (p < 0.001). While global cognitive impair

SUBMITTER: Pengo M 

PROVIDER: S-EPMC9385756 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature