Newly diagnosed diabetes mellitus is a risk factor for cardiocerebrovascular events in primary aldosteronism.

ABSTRACT:

Objective

To explore the prevalence and clinical significance of newly diagnosed diabetes mellitus (DM) in patients with primary aldosteronism (PA). Investigating the risk factors for cardiocerebrovascular disease (CCVD) will guide strategies for reducing CCVD in patients with PA.

Methods

We retrospectively included 729 PA patients without DM and conducted oral glucose tolerance tests.

Results

We found that 15.0% of PA patients had newly diagnosed DM. The DM prevalence increased with elevated aldosterone levels [OR = 3.20 (1.77, 5.78), P value < 0.001]. The rate of CCVD in newly diagnosed diabetic PA patients was higher than that in nondiabetic PA patients at diagnosis (11.9% vs. 5.0%, P = 0.005). Furthermore, multivariate logistic analysis revealed that HT duration [

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9385765 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature