Cognition and motor phenotypes in ALS: a retrospective study.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) is phenotypically heterogeneous in motor manifestations, and the extent of upper vs. lower motor neuron involvement is a widespread descriptor. This study aimed to examine cognition across different ALS motor phenotypes.

Methods

ALS patients (N = 124) were classified as classical (N = 66), bulbar (N = 13), predominant-upper motor neuron (PUMN; N = 19), and predominant-lower motor neuron (PLMN; N = 26) phenotypes. Cognition was assessed with the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and function with the ALS Functional Rating Scale-Revised (ALSFRS-R). Revised ALS-FTD consensus criteria were applied for cognitive/behavioral phenotyping.

Results

Defective ECAS-total scores were detected in all groups - bulbar

SUBMITTER: Aiello EN 

PROVIDER: S-EPMC9385798 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature