Impact of the dead-time correction method on quantitative ¹⁷⁷Lu-SPECT (QSPECT) and dosimetry during radiopharmaceutical therapy.

ABSTRACT:

Background

Dead-time correction is required for accurate quantitative SPECT-based dosimetry in the context of personalised ¹⁷⁷Lu radiopharmaceutical therapy. We aimed to evaluate the impact of applying dead-time correction on the reconstructed SPECT image versus on the acquisition projections before reconstruction.

Methods

Data from 16 SPECT/CT acquisitions of a decaying ¹⁷⁷Lu-filled phantom (up to 20.75 GBq) and dual-timepoint SPECT/CT in 14 patients treated with personalised ¹⁷⁷Lu peptide receptor radionuclide therapy were analysed. Dead time was determined based on the acquisition wide-spectrum count rate for each projection and averaged for the entire acquisition. Three dead-time correction methods (DTCMs) were used: the per-projection co

SUBMITTER: Desy A 

PROVIDER: S-EPMC9385894 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature