Identification of programmed cell death-related gene signature and associated regulatory axis in cerebral ischemia/reperfusion injury.

ABSTRACT: Background: Numerous studies have suggested that programmed cell death (PCD) pathways play vital roles in cerebral ischemia/reperfusion (I/R) injury. However, the specific mechanisms underlying cell death during cerebral I/R injury have yet to be completely clarified. There is thus a need to identify the PCD-related gene signatures and the associated regulatory axes in cerebral I/R injury, which should provide novel therapeutic targets against cerebral I/R injury. Methods: We analyzed transcriptome signatures of brain tissue samples from mice subjected to middle cerebral artery occlusion/reperfusion (MCAO/R) and matched controls, and identified differentially expressed genes related to the three types of PCD(apoptosis, pyroptosis, and necroptosis). We next performed functiona

SUBMITTER: Shu J 

PROVIDER: S-EPMC9385974 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature