Improvement of the bladder perfusion curative effect through tight junction protein degradation induced by magnetic temperature-sensitive hydrogels.

ABSTRACT: Postoperative intravesical instillation of chemotherapy is a routine procedure for non-muscular invasive bladder cancer (NMIBC). However, traditional bladder perfusion methods have insufficient exposure time, resulting in unsatisfactory therapeutic effects. In the present study, a chitosan (CS)-based in situ forming depot (ISFD) delivery system, including Fe₃O₄ magnetic nanoparticles (Fe₃O₄-MNP), CS, and β-glycerophosphate (GP) as main components, was synthesized. Pirarubicin (THP), as a chemotherapeutic drug, was loaded into the new system. Results showed that our carrier system (Fe₃O₄-THP-CS/GP) was converted into gel and attached to the bladder wall, possessing loose network structures with magnetic targeting and s

SUBMITTER: Sun X 

PROVIDER: S-EPMC9386042 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature