Ontology highlight
ABSTRACT:
SUBMITTER: Yan SH
PROVIDER: S-EPMC9386086 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Yan Shi-Hai SH Hu Li-Mu LM Hao Xue-Hui XH Liu Jiang J Tan Xi-Ying XY Geng Zhi-Rong ZR Ma Jing J Wang Zhi-Lin ZL
iScience 20220720 8
Colorectal cancer is one of the most serious tumors and berberine can inhibit the recurrence and transformation of colorectal adenoma into colorectal cancer. However, the direct binding target proteins of berberine in inhibiting colorectal cancer remain unclear. In this study, the chemical proteomics method was used and demonstrated that berberine is directly bound to pyruvate kinase isozyme type M2 (PKM2) in colorectal cancer cells. The triangular N-<i>O</i>-O triangular structure of berberine ...[more]