Association between polymorphisms and hypermethylation of CD36 gene in obese and obese diabetic Senegalese females.

ABSTRACT:

Background

Obesity and related metabolic disorders are associated with genetic and epigenetic alterations. In this study, we have examined the association between polymorphisms and hypermethylation of the CD36 gene promoter with obesity in Senegalese females with or without type 2 diabetes mellitus to identify novel molecular markers of these pathologies (obesity and type 2 diabetes mellitus).

Materials and methods

The study was conducted in Senegal with healthy lean control, obese, and obese diabetic (age; 49.98 years ± 7.52 vs 50.50 years ± 8.76 vs 51.06 ± 5.78, and body mass index (BMI); 24.19 kg/m² ± 2.74 vs 34.30 kg/m² ± 4.41 vs 33.09 kg/m² ± 4.30). We determined three genetic polymorphisms of CD36 i.e., rs1761667, rs1527483, and rs32118

SUBMITTER: Toure M 

PROVIDER: S-EPMC9386198 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature